Getting out of the saddle periodically helps.
Finding a good saddle can be tough. I now use SMP saddles with a full length cutout. I got the right width, just based on what they call pants size, which means waist size, at least for those not carrying excess weight. I needed a narrow model and the Stratos with standard padding did the trick.
It's also important to have a seatpost that allows fine adjustments to the saddle angle and a digital level to measure the saddle angle. I always use a post with a 2-bolt rocker style post like the FSA K-force that has a 25mm setback. Posts that rely on serrated notches won't allow small changes to saddle angle.
Having good quality shorts with a good pad is also a must. Don't cheap out on the shorts.