My Fuji Sportif set up for maximum comfort .... first from 2017, second from 2020, I think. The hoods angle up slightly from the top of the bars, which are pretty much horizontal, so I can rest the heels of my hands on the bars and the palms on the hoods. Most people have the radial and ulnar nerves running pretty much up the middle of their hands, and if they press between the pad of the palm and the pad beneath the thumb they will pinch those nerves. I always make sire to have the bone at the far outside of my hand, under my little finger, resting on the bars, so I don't press on the nerves. I still have to shake out my hands from time to time but I don't get numb.
I have bikes with more seat-bar drop, but for long rides, riding tired, or hauling loads I find the smaller drop more comfortable. I experimented a lot to find good rising positions for each of my bikes.