I would never use a 1X, especially with a Shimano STI shifter. It has everything to do with fatigue in my right foream muscles. The long throw of the brake lever shift is very similar to a wrist curl(for me). Over the course of an all day ride, those muscles get tight. I get to a point where I can't squeeze the brake lever. I use a triple and Microshift shifters. One or 2 shifts of the front and 3-4 shifts of the back will cover a large part of the range. Way less shifting to go from your smallest to your largest gear and visa versa. I don't care if I have redundant gears. What I care about is having options.