I have a Hollywood frame rack I use. When I am going any distance, I take the front tire off. if I am just going across town to the bike trail, I don't mess with taking the tire off. Most 4 bike bike racks would handle the weight of a single tandem.
I have used my 4 bike Hollwood rack with my two other adult bikes. I was a little worried about the bounce when I took this picture last summer.