I would expect it to negatively affect shifting.
Jumping from 50 to 52 teeth, with an 11-tooth rear sprocket, on a road bike, with a 90 rpm cadence, should let you ride some 2 km/h faster (from about 52 km/h to about 54 km/h).
Sounds like a silly idea to me, but it's your bike, your choice, and if you think it is cool, the only price would be a bit slower front shifting, most probably.
Relja