That weird reverse snobbery is not uncommon around online forums. "With absolutely no regard for my scrotum--which I am prepared to chafe so badly it glows in the dark--I wear cut off jeans with cotton underwear and t-shirts like it's 1975 to prove a single point. Anyone who dares to wear appropriate cycling clothing is a poseur who cannot keep up with me when I lay down the wattage on my humble old velocipede and I will pass them at speed, laughing all the way at their vanity, dressed as they are for the Tour de France (the only race that I know of really, but you get my very valid point). I. Am. Better. Than. Them."
Aside from that, the contact points are important. I always change pedals from the place holders bikes sometimes come with, the saddle and the grips. Guys will also change bar tape with gel pads etc. A decent bike fit and changing the contact points are the main things for comfort, though.