Do you check your tires pressure before you ride your bike? If not, then you might actually be getting pinch flats. They don't always have the two punctures that earn them their other name as snake bites. Every flat needs to be diagnosed. Lay the tube out on the wheel rim as it was oriented in the wheel, then inflate it to find the leak. Is the hole on the tread side, rim side or sidewall? If you are on the roadside in a hurry, put in the new tube and save the old to check at home.
I am just about to wear down the GP5000 on my rear to the threads showing. I haven't flatted since putting it on over 2 years ago.
If Gatorskins didn't help you, then I'd suspect many of your flats aren't from road punctures. So getting rid of the tube and going tubeless might be helpful. So consider it if you are up for that understand the new things you'll have to do every great once in a while.