Hands and wrists developed intense pain, which forced me to only ride bikes set up to be upright enough that there was no weight on the hands. Then a few months later intense back pain appeared, and made riding seemingly impossible. That was quite the dark period. After a few months decided to try and make a full-suspension MTB as upright as possible, and found I could ride again. The pain has gotten more manageable as time goes on, but still can't ride a rigid bike for anything more than a short test ride.