Originally Posted by
grumpus
Vertical dropout takes the pedaling force, which skewer has to counter with horizontal dropout. Rim brake produces minimal vertical reaction force, which skewer has to counter with disc-brake. So your skewers don't have to do much, mainly just hold the wheels up in the dropouts until you sit on the bike. Important that they don't chew up your CF while they do this, so an aggressively knurled skewer cranked to the max is best avoided.
I wasn't thinking about braking, but just riding/descending, taking fast turns, where forces have different directions (more like trying to twist the frame or rotate the wheels along bike's horizontal axis)