My normal brevet bike has a 46/34 on it now. I wanted a 44, but 46 are easier to get. The problem with the GRX is the more expensive ones come with a 48 minimum, which means the smaller chainring is also larger. So I would have to buy a cheaper crank for the chainrings. Or just stick with the cheaper crank.
Using a 46 is so much better than a 50. I don't have to shift the front as much. I used to wear out the 17 and 19 tooth cogs on cassettes, but cassette wear is much more even now.