Sample of one, so take it for what it's worth.
As a one-handed rider, I have been upended by front end challenges more times than I would care to admit - rumble strips, railroad tracks and the like.
The current generation of Domane - I've had all three - is by far the best at handling both the unexpected and expected jolts that happen on the road.
I raced it on gravel on a fairly rugged course, running 40mm gravel tires. It was competent but scary on the washboard descents. The ISO front was barely noticeable in the rough sections.
The Checkpoint I now ride for gravel is at home there. Because the challenge is constant, I'd be hard pressed to think of a ride that would have been better on the Domane.