According to bicyclecalculator the answer is NO (but maybe YES :-)
Riding 100mph in 0mph wind takes 21508w
Riding 50mph in 50mph headwind takes 10754w
Riding 1mph into a 100mph headwind takes 219w (this seems completely wrong)
and
Riding 100mph in 100mph tailwind takes only 182w (seems reasonable, because relative wind speed is zero)
Riding 50mph in 50mph tailwind takes only 91w
Meaning, as expected, at high speed power to overcome rolling resistance is negligible compared to power to overcome wind resistance.
However, I can offer no explanation as to why 100 + 0 mph takes so much more power than 50 + 50, when relative wind speed seem to be all that matters. Imo they should be MUCH closer.
Tbh, I have a suspicion its an anomaly/mistake in the calculator.
bikecalculator.com/