After using STI levers for 16 years, I wanted my then-new Di2 bike to shift in the same manner -- so I did not get creative with the programming. I'll bet virtually all Di2 users stick with the standard configuration. On the other hand, I have used the top-of-hood auxiliary buttons for a couple different purposes over the years -- at first they were secondary rd shifters (left button UP the cassette, right button DOWN the cassette), but now they are programmed to flip the page on my computer screen.