one thing to be aware of if you use clipless pedals - and run and/or have issues with shins ('shin splints', ischemia, etc)
you can tax your shins a bit more when using clipless pedals - especially if you ride with your saddle set relatively high
if you are a frequent runner you then could be more susceptible to shin and related problems
(again - can / could - many triathletes and similar log a zillion miles training with clipless pedals and long distance running with little / no issues)