I use a 53/39 and 11-32 sram 11 speed cassette on a couple of road bikes. I use 50/34 and 11-32 on my gravel/touring bike. Most of myroad riding uses a 1X setup AXS with 48T and 11-34 12 speed cassette although I do mount an 11-39 for hilly conditions....not ideal but not bad either. Currently trying to figure out a new bike or finding one available. I am probably going with 48/35 and 10-33 if SRAM and 52/36 and 11-34 if Shimano. Both would be fine for me as most of my hills are 9-11% with a few in the 13-16% range
It really comes down to preferred cadence and W/Kg you are willing or able to put out.