A e-bike for cargo is fine if the items can get wet and one is only making a single stop and no worries about theft of the cargo and or the bike. Having a 80 lb cargo bike rig would make it less attractive to thieves.
Important in cities with drainage grates along the curbs to be careful with narrow tires that can slip down between slots. Some cities have welded cross bars along bike routes but I would not count on this being universal.