That is one clean looking bike. Not a fan of the big S but that's hot. Shimano really downplays the capabilities of GRX as a whole which is weird to me. I am running mechanical 800 with the 42t crank and the 11-46t cassette which Shimano says you can't do but the B screw had more than enough room to spare and honestly it might even clear the 10-51 but my wheels aren't micro spline to give it a try. Only downside I found is that no one makes a really long chain lol so I had to splice together 2x of them.