It's hit and miss. I have worn shorts from multiple makers from economy level to stupidly expensive. Thicker padding often as not is less comfortable than thin padding, and you need to try a few different brands and designs to find what works best for you. If and when you find the "magic" shorts, buy as many as they have, because you can bet your bottom dollar that the'll be replaced with a newer and less comfortable version before they wear out. The most comfortable shorts I ever wore were Assos Sportsline with genuine chamois padding. These cost less than half as much as the Prosline, but were twice as comfortable.