The first question is if your wife has ever used the 50-11 combination? If not, dump the 50t.
Both my bike and my wife’s are setup with triples, but I don’t think that is an option with an 11 speed. I would go to a 46-30 subcompact crank. Maybe a GRX RD and run an 11-34 or 36.
I’m not up on the 11 speed stuff but I think GRX will work with Ultegra shifters.
John