I have chronic spinal issues that cause quite a bit of discomfort and pain. However, my most painful daily challenge is my arthritic left thumb. It affects so much every day. It is one of the reasons I have been trying out different set ups on my bikes. I have found that I really like Velo-Orange Porteur bars, and now have them on my Poprad. I ordered another one, but will have to see which bike it will wind up on. It eliminates most of the pressure put on the thumb when biking with drop bars.