I have SRAM Red AXS. My hand like the shape of the brake lever. Wireless is very easy to setup. My system is a bit of a franken build. I think the rear derailleur is ugly. It seems to shift faster than my 11S etap. The blip box and blips work for me due to some hand/arm disability
The Shimano 12S Dura Ace is not yet available and it is questionable whether one could get a grouppo before late Spring IMO. One drawback if you have rim brakes is the wiring complexity for that setup. A big advantage is battery life. If I were going for a completely custom build, it would be Dura Ace. I like that they stuck with 11T as the smallest sprocket and the group does not have as many imposed compatibility constraints as SRAM's marketing geniuses imposed. Just my opinion.