How low of a pressure are you running? I would replace the tube in question ASAP or better yet go tubeless.
Apply a good coat of baby powder to the inside of the tire prior to mounting. This will reduce friction and let the tube move inside the tire more freely. As you inflate the tube stop and bounce the wheel to let the tube straighten. Run the pressure well above your riding pressure during this process. Back off the pressure and ride.
I ride in the desert and am a huge fan of tubeless for the puncture sealing properties.