The only supplements I take are calcium with vitamin D and B12. The calcium/D hs no effect. The B12 definitely helps my energy level, mood and sleep. I stopped taking it for a while due to having a very high level of B12 with my last lab work. I started taking it again 4 or 5 days ago and I have slept better the past couple nights. That alone, of course, helps the energy and frame of mind. I really have no valid comment other than that.