I had Hylex hydro brakes on my bike and replaced them with Spyres and RRL levers. I hated the shape of the Hylex lever hoods (subjective) but without doing a bunch of risky experiments, I don't know that any other levers would work with Hylex calipers. Using mechanical brakes allows menthe freedom to use whatever cables and levers I want.
the Hylex system has a little more stopping power, but this is a bike ridden on roads and smooth singletrack—it's not a trials bike—so the braking performance of Spyres is more than sufficient.