I have installed and used the Spyre, BB7, Tektro, Shimano, etc. etc. etc. The mechanical brakes seem to preform much the same, provided one sticks with a known quality brand such as Avid, Spyre, Shimano, etal, and not the low end junk from Formula and others like them. As for adjustment, the BB7 is likely the easiest to adjust, however the two sided action of brakes like the Spyre makes for quick adjustment as well.
Only one complaint about Spyre brakes has been already mentioned. The 2.5mm pad adjuster. Does not instill confidence at all, and cannot be ham-fisted in any manner. If you ride in foul environments on a full-time basis, that 2.5mm adjuster can become a problem due to corrosion. Discovered this on my son's commuter bike, and for this reason I have a set of BB7's sitting in a box waiting for a frame to install them on. Doubt I will ever do it since rim brakes work just fine for me. Anyone need a BB7 caliper set?