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Old 09-23-22, 06:53 PM
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Carbonfiberboy 
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Bikes: CoMo Speedster 2003, Trek 5200, CAAD 9, Fred 2004

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I tried several statins several years ago, both lipid and water-based in several dosages (they're so cheap!). They all had a bad effect on my power, plus they made my muscles sore after even moderate exercise. On our tandem, my wife said it was like I wasn't there anymore. I quit them, still alive. I got my cholesterol levels better balanced, mostly by nutrition.

I looked around for about 10 minutes and found this study, which might explain your symptoms: https://onlinelibrary.wiley.com/doi/10.1002/jcsm.12654
I also looked around for connections to glycolysis but couldn't find anything definite other than the above. The statin thread is the geezer forum seems to say that about 20% simply can't tolerate statins.

The really interesting thing about statins (and I don't remember where I saw this) is that cholesterol levels per se aren't strongly associated with cardiac events and that what statins really do is that they change the deposits in your heart's arteries to a more solid substance which doesn't break loose and cause blockages. High levels of endurance exercise do the same thing. See:
https://bmjopen.bmj.com/content/6/6/e010401

Unfortunately, the statin industry has taken over heart disease research. It's become hard to find unbiased research. As my PCP says, "Cardiologists lose their license if they don't prescribe a statin."

You should try taking 100mg of ubiquinol morning and evening. See if that helps. That helped me a little but not enough to make me a happy cyclist again.
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