Both the front and rear DR's? If just the rear won't shift, have you made certain it's not in crash mode?
If you have loaded e-tube project then you should be able to see every Di2 component and determine what it is supposed to do when pushed. You can reconfigure some buttons and levers to do other than their intended function. It might be that you haven't enabled them.
This site has helped me quite a bit.
https://bettershifting.com/ Lots of good info if you browse through it.
https://bettershifting.com/frequently-asked-questions/