Are the other spokes bladed? Might be 80 extra for lighter and more aero which makes for a better overall value. If you did two wheelsets and ran them back to back on the same climb with the same bike you'd possibly notice the difference but otherwise you won't really notice much of anything at all. If weight is a concern are you already running alloy nipples for a better weight savings? Some people are anti them as they are less durable than brass but at the end of their lives I haven't had any wheels who's failure was due to nipples, alloy or brass. For just lighter, I wouldn't, for lighter and more aero I would.