Originally Posted by JohnDThompson

Absolutely serious. It takes maybe ten seconds to remove or install a brake pad; much less time and effort than deflating and reinflating a tire with a hand pump.

But @Rick Makes a good point re: the caliper release cam. If you adjusted your pads close to the rim with the caliper release in the open position, you won't be able to get more clearance when you try to remove the wheel.