You know, one advantage to modern disc brakes is that you aren't limited to one tires size, necessarily, but not even to one wheel size! Sure, that's possible with some rim brakes, too, but it's easy peasy to swap out those wheels. Case in point, went touring on this one a week or so ago with 650B x 42mm wheels and fenders:
Last year, I took it bikepacking with 700 x 32 wheels (and carbon rims, which I later destroyed):
Fwiw, I really can't tell much of a difference between the ride of the two sizes.