It is nearly always worth it if you are not overly cost conscious and build something you can’t buy.
For me the key is a successfully mix-n-match to end up with a product that specifically suits your needs. But you need to do your research first.
My brother ran an XT crank on his touring bike with 22-34-44 and an 11-32. His 44-11 gives him enough top end and 22-32 is almost one ratio above walking. It is perfect for him.
None of the bikes I have built have “groups”. Each component is more purposefully thought out.
John