Originally Posted by
Carbonfiberboy
What does that bolded sentence mean? Source? Does that mean that gains are reliant on NMN blood concentrations, take that away and you're back to zero?
It was some mouse study where the control did better after supplementation was stopped:
https://pubmed.ncbi.nlm.nih.gov/32365524/
If you want to read lots of very noisy discussion on NAD+, NMN, NR try the NR Re-ddit channel, that is where I found mention of this study.
https://www.******.com/r/NicotinamideRiboside/ (put Re-ddit minus dash in for stars)
EDIT: I had time to read the above article just now, I think the Re-ddit comment was noise as I could find no mention of what was asserted to be in that study by the Re-ddit poster. Still it is an interesting article enumerating many potential negatives based on rodent studies using much higher doses. Here is the article which shows how withdrawal of supplementation caused the study group to be beaten by the control.
https://www.nature.com/articles/s41514-021-00078-3 . Note it is with NR which is a different NAD+ precursor.