Originally Posted by
mstateglfr
My calves aren't happy, but my quads are straight up angry.
Your seat is definitely too high and you're pointing your toes down excessively on the down stroke. High seat is easy for quads but hard on the calves.
Drop your heel and seat a bit to put less work on the calves and more to the quads, glutes, and hamstrings. Helps even things a bit.
Nothing seems to be wrong with your hydration and fueling. If there is, your whole legs, not just the calves will bonk out.