Your experience may be different, but...
The folders I have ridden suffered badly from two problems. First the tall masts made the bike flex like crazy and second I was not able to get a cockpit position I liked on the ones I rode. I own a Dahon Helios and it is okay for short rides around town to run short errands but much more than that is a stretch especially if there is any climbing involved, When the road tilts up the flexy masts really become apparent.
The Bike Friday is said to be better than the run of the mill folder by some of it's proponents, but I'd want to have a long test ride in varying conditions before I committed to the purchase. I am a skeptic, but have not ridden a BF.
On folders I have ridden I didn't find the small wheels to be the problem so if they make a rigid frame that allowed a position you like it may work well.