When you say you “indexed”, you checked / trimmed with either shifter adjustment or etube software?
if you did do this without the software by going into the adjustment mode and jogging the RD with the shifter buttons, I’d try again……easy to lose your reference point….I prefer using the software…
Another possibility, is a very slightly bent Derailleur hangar….have alignment checked …..
How old = worn are the cassettes?
Last edited by 55tele; 06-02-21 at 08:57 PM.