Might be the wheels not properly dished for that bike or you have a spacer on the wrong side if there is a spacer involved.
However I once had a wheel wonky in the dropouts and it seemed centered between the seat stays and brakes, but I failed to notice it wasn't between the chain stays. I rode it for probably weeks to a month or more like that and had quite a bit of tire wear.
I was able to see the error and apparently on that bike it was the slop in the slot in the drops being a tad wider than the axle that helped make the error. They were also horizontal drops similar to yours.
Also, I've never had my alignment screws in the drops screwed all the way in. I suppose if that puts your cassette optimum for the DR and your drops are actually in perfect alignment with each other then that works. But maybe check to see that isn't an issue.
Never seen so much room on the left of the hub. Is this same frame also for bikes spec'd with disc brakes?
Last edited by Iride01; 10-09-22 at 11:45 AM.