Seems you’ve done some homework. As noted, it’s up to each frame. Space for tire size is a consideration. Other things like frame type, endurance, race, etc...
as this is your 1st roadie in a while, if you have a consideration for wet rides, I wouldn’t start/go with rim. rim will be around for quite some time, but disc will be all the new stuff.
As for real changes in frame tech, materials , as in bike weight, performance has been evolutionary. Rear dropout width has been 130 for quite some time and seems to continue for short term roadie future. Gravel is, however, propelling the change there. That and 12 sped drivetrains will likely cause rear ends to evolve.
as much as I like 10 speed, in your case, wanting a performance machine, would have get nothing lower than 11 spd.
Ride On
Yuri