Clark W. Griswold
Join Date: Mar 2014
Location: ,location, location
Posts: 13,538
Bikes: Foundry Chilkoot Ti W/Ultegra Di2, Salsa Timberjack Ti, Cinelli Mash Work RandoCross Fun Time Machine, 1x9 XT Parts Hybrid, Co-Motion Cascadia, Specialized Langster, Phil Wood Apple VeloXS Frame (w/DA 7400), R+M Supercharger2 Rohloff, Habanero Ti 26
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Without knowing much of anything based on what the OP wrote, I would say White Industries hubs laced to Velocity or H+Son rims with Sapim spokes and their Secure lock nipples. If you are a lighter weight rider and not carrying a bunch of stuff I might say go 28h. The handbuilt wheels are going to be nicer quality wise but may not do much else unless they happen to be lighterweight. The bearings will be better but beyond that it is really just weight that would be the biggest concern.
However a better wider and more supple tire at lower pressures will probably do a lot more than a wheelset would unless that wheelset is significantly lighter.