I have been running tubeless sealant in my fat bike. The problem with it is, when you get a large puncture which the sealant wont seal, and need to patch it, a little sealant leaks out, and prevents the patch from sticking.
After thinking about it, I might get a puncture which the sealant will seal, on average once a month, and I might get a large puncture which the sealant wont seal, on average once a year. So I am back to running sealant in my tubes.
I am now going to motorbike tubes in my fat bicycle.
I am also using a different brand of sealant.
I shall see how it all goes.