Pretty much all standard road tires have a puncture protection layer of some sort; the GP5000, too. Only dedicated timetrial tires don't and you'd know if you were buying those, and possibly the cheapest tires don't because they're just cheap. Run tubeless with sealant, you will likely have no problems with flats, although not carrying any means to get your bike going if something happens is... not advisable. Not even on Gatorskins, Schwalbe Marathons and other really resistant tires.