The big aero brands certainly make some aspects of maintenance difficult with the way they run housing through the head tube. I suggest looking into that before buying, that's for sure. I don't think I have seen as much complaining about the Domaine, but my memory fails a lot. OTOH, you can get it serviced ahead of any big rides.
The way the PBP mechanics in 2019 seemed stumped by just about anything that wasn't 10 years old was a bit disconcerting. If you had 11 speed, they couldn't help you.
I think big sizes are particularly challenging right now. In the before times, the 6'5" people I know had their choice of bikes nobody would buy because they were too big. Nowadays, I think the brands just didn't have bikes that size made.