Not only with bikes that take larger tires, but those that have provisions for fenders, such as the Trek Domane. The Synapse has fender eyelets on the fork and rear dropouts so had I known before that these bikes have different component requirements than the rest of the road bikes I would have gone a different route away from the 105.
Perhaps it's true that having the LBS do the work can save me time and money. But I like to tinker with my bike. By doing so, I become more in-tune as to how it behaves while I'm riding it and make adjustments to my liking right away.