I've never had anything stop me from continuing the ride, no matter how long. That said, I've never done anything tougher than a mountain 400.
Hand problems have been solved by the right gloves and continuously changing grip.
Arm problems have been solved by hard work in the gym.
Butt problems have never gone away completely, but have been made tolerable by me going through several cardboard boxes full of saddles and many different models of shorts over the years.
Leg problems have been solved by lots of gym work and progressively longer and harder fast group rides.
Foot problems have been solved by the right shoes and socks, in my case Sidi Dominators and SPD pedals with various different pairs of socks. It probably also helps that I pedal circles with as little downforce as I can manage on long rides. It probably also helps that I do long walks and hikes and backpacks in the mountains. Specialized has insoles which have various shapes to help with ball of foot issues.
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Results matter