My last triple setup was Campy 10 speed with a 53/39/28 crank and 12-25 cassette. It worked fine. I rode 5,000 miles per year in the Colorado mountains with it, for five years, including 6 trips to the top of Mount Evans. My best time was 2:35, when I was 53.
I switched to a compact 50/34 with an 11-27 in 2008, the first year of 11 speed. It worked fine too. Fast forward to July of 2018. I'm 65 with two replaced knees. I'm just getting back into cycling after 8 years off. I start with my 2004 model LOOK KG461 that has the same 50/34 and 11-27 cassette, but my current terrain has steeper 10% climbs. I switch to an 11-32 cassette, but as an old beginner-again, I could use a little lower gear. In 2019, I get Campy chorus 12 speed with a 48/32 crank and 11-34 cassette. In 2020, I switch to SRAM Force AXS with a 10-36 cassette, but same 48/32 crank. In October I switch from rim brake frames to disc and experiment with 46/30 and 48/31 cranks.
I have not found the jumps between sprockets to be too large, except on the 10-36 that has a 13-15 jump. The 24-28-32-36 changes work great on steep climbs. I just ordered a 10-33 cassette, as my strength has improved after 3 years and 14,000 miles back on the bike. It has 10-11-12-13-14-15-17-19-21-24-28-33 sprockets. Some complain about the 28-33 jump, but I expect no problem.