Originally Posted by
Polaris OBark
The center-lock Shimano rotors seem to have better heat dissipation fins than their six-bolt counterparts. That's a design choice, rather than some inherent limitation of the attachment mechanism, but it might lead to better performance (my splined rotors seem to last a lot longer than my 6-bolt ones).
I have become a big fan of Shimano hubs. I highly recommend the GRX hubs as high quality and very good value. And, they happen to be center-lock which I like.
Shimano GRX FH-RS770 Disc CL Hub