Yeah, there used to be many, like back in the 70s and ‘80s. Peugeot were big around my town, and my sister had a Lotus mixte which had Columbus tubing, as I recall.
As for today’s high-performance, though, I don’t think so. Modern mixtes are retrostyled even if they use cromo tubing; 1” head tubes, steel forks, and stuff like that.
I ran into Polish brand Creme at a bike shop in Riga Latvia, and they make a nice looking, decently tubed, classically sporty mixte called Echo. They have pics of a drop bar variant, but I don’t see it in the lineup, just flat bar:
https://www.cremecycles.com/lady-echo-series,22,pl.html
Linus also make a handsome mixte, but Hi-Ten tubing. A lady in my hood has one in a khaki green color and looks so good riding it!
https://www.linusbike.com/collections/mixte-3i-mixte-7i
Custom would be the way to go for a performance mixte frame, I suppose. Dunno who, exactly, but seems like any skilled builder could do one, but would probably have to fish around for all high-end tubes, as I’d suspect they’re not many that have the long, thin, Tt-to-rear triangle tubes. As a styling exercise, I think that’d be a cool project.