I'm in a similar situation to jpescatore. Similar age, similar weight (but I've yet to lose that 20lbs!). I ride a 2014 Carbon Domane, and I love it. I also have a 1999 Lemond Zurich with a full Ultregra R8000 groupset. Some observations:
The CF Domane rides very nice. I have a Ritchey CF (Pro Logic II IIRC) handlebar on it, and the handlebar DOES make a difference.
The Lemond (853) also rides ok. I enjoyed it, but when I swapped out the original fork for a Ritche WCS, with the pro logic handlebars, it made a big difference. It rides super.
I defer to jpescatore's experience with aluminum.
BTW, I weigh about 245 and have had the Domane wheels with Trek Paradigm wheels (18 spokes?) and so far... no spoke breakage. Maybe my legs are just weak.