Originally Posted by JohnDThompson

If "winning" is defined as minimizing chain wear, then an enclosed chain case such as found on some "city" bikes is a "winning" answer. But those come with their own issues (no derailleur, so single speed or internally geared hub, additional hassle in removing rear wheel, additional weight). Another "winning" answer is a lubricant-free belt drive, with fewer complicating issues than an enclosed chain case, but not issue-free (again, no derailleur, split rear stay to allow belt installation and replacement).