If this is what you really want, I'd probably just advise you to not take any shortcuts and do a 46/30 crank with an 11-36 cassette (just out of spec) with the correct derailleurs. Larger cassette than that may or may not work but I haven't had the chance to try it.
I'm pretty sure if you want you can also run a MTB Di2 RD 1x with road shifters, which officially max at 11-46 but would probably work OK with a 50t.
I'm all for 1x, but currently still not quite there for me for a bike that gets ridden on asphalt and gravel somewhat evenly.