The above illustrates my pet peeve about threads asking for “the best.” Some prefer compartments. If you do, Ortlieb’s will not be the best for you. (Note that the Packer series does have some minimal compartmentalization.) I used to use highly compartmentalized bags and thought I would mind the Ortlieb style, but I ended up not minding. But some people want something different. You need to refine your wants to know what will be best for you.